PPTOXII: Role of Environmental Stressors in the Developmental Origins of Disease

(Prenatal Programming and Toxicity)

December 7–10, 2009
Loews Hotel, Miami Beach, Florida

 

Registration Form
Poster Presentations
Speaker Abstracts
Student Travel Award Recipients

Index

Poster Information	Program
Poster Presentations	Organizing Committee
Hotel Information	Registration Information
Location	Sponsors
Previous SOT CCT Meetings	Transportation
Press Release

Background

Fetal and early postnatal development constitutes the most vulnerable time period of human life, in regard to adverse effects of environmental hazards. Subtle effects during development can lead to functional deficits and increased disease risk later in life. This hypothesis, which states that environmental exposures lead to altered programming leading to increased susceptibility to disease/dysfunction later in life, has gathered much support from both experimental and epidemiological studies. Indeed there are experimental data for the role of developmental exposures to environmental chemicals for male and female reproductive diseases/dysfunctions, prostate, breast and uterine cancers, cardiopulmonary diseases/dysfunctions, neurobehavioral problems, and neurodegenerative diseases and immune and autoimmune diseases. Exposure to environmental chemicals during prenatal and early postnatal environment affects gene expression and the resulting epigenetic changes may constitute an important mechanism for the programming effects. Since the epigenetic system is most vulnerable to disruption during specific times during development, timing of environmental exposures is critical for their effects on disease etiology. It is also apparent from animal studies that epigenetic changes due to environmental exposures during development can be used as biomarkers of both exposure and potential future disease or dysfunction.

The first PPTOX conference took place in Torshavn, Faroe Islands in 2007.

Objectives

The objective of the conference is to examine the animal and human data supporting this hypothesis (developmental basis of disease) disease by disease in order to review the current state of the literature and to identify mechanisms for the effects as well as to identify research gaps and challenges and to integrate the basic and applied science. Because of its International nature, the multidisciplinary and interdisciplinary nature of the speakers, and the attendance and participation of students from multiple disciplines, we expect this meeting to stimulate collaborations that will lead to the development and validation of biomarkers of exposure and disease susceptibility, improvement of exposure assessment and extrapolation across species and routes of exposure.

Product

The products of this meeting will include knowledge of the state of the science, the development of collaborations among participants and the development of an overview of the conference report in Toxicological Sciences as well as publication of the presentations in other journals focusing on the developmental origins of disease paradigm.

Poster Information

Poster Presentation Dates, Time and Order:

Tuesday, December 8 from 6:00 PM–7:30 PM the Even Number posters will present.

Wednesday, December 9 from 6:00 PM–7:30 PM the Odd Number Posters will present.

Poster Presentation Numbers, Authors and Titles

Press Release

Scientists Explore Role of Environmental Stressors in the Developmental Origins of Disease—Experts from around the world are gathering in Florida to examine the animal and human data supporting a hypothesis that subtle effects during fetal and postnatal development can lead to functional deficits and increased disease later in life. Read more information about the second International Conference on Fetal Programming and Developmental Toxicity (PPToxII).

Abstracts and Poster Presentations

All abstracts will be published in the on-site binder for the meeting as well as on a secure site on the SOT Web site so attendees of the meeting can view them on-line. Abstracts should describe the aims of the work, methods, and the key experimental findings in a clear and succinct manner. Brevity is important. All abstracts will be reviewed for scientific content and the Abstract Committee reserves the right to refuse abstracts that do not adhere to publication guidelines. It is hoped that abstracts and posters will be the first presentations of the study represented; however, abstracts previously presented at national/international meetings are welcomed.

Poster Presentations

Poster Instructions

Student Travel Award Abstract Competition:
Travel awards winners will be selected from among the students or postdoctoral students who submit abstracts for presentation in the poster session. Abstracts will be chosen for the awards based on review by a committee and based on the scientific quality of the data described in the abstract. It is necessary to identify that you want your abstract to be included in the competition for the awards. Applicants must also be registered for the meeting. The travel award will be for $500 US and will be given on-site. Award notices will be given out by November 20.

Student Travel Award Abstract Competition Eligibility Criteria:
Eligible Graduate Students and Postdoctoral fellows (<5 years), and European early career lab heads. Candidates may come from within academia, contract research organizations, pharmaceutical or biotechnology industry, and government organizations engaged in preclinical research in reproductive and developmental toxicology. Students are encouraged to apply. The research field can be any area of scientific novelty with application to PPTOX.

Program

December 7–10, 2009
Loews Hotel, Miami Beach, Florida

Day 1
Monday, December 7, 2009

Session I Overview

Time	Topic	Speaker
3:00 PM–5:30 PM	Registration
4:00 PM–6:00 PM	Hors d'oeuvres  and Refreshments
6:00 PM–6:05 PM	Welcome, Introduction, and Meeting Objectives	Jerrold Heindel, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
6:05 PM–6:10 PM	Welcome	Cheryl Walker, SOT President, MD Anderson Cancer Center, Smithfield, TX, United States
6:10 PM–6:25 PM	Global Perspective on Children’s Environmental Health	Roberto Bertollini, World Health Organization, Geneva, Switzerland
6:25 PM–6:40 PM	National Institute of Child Health and Human Development Perspective on Children’s Health	Germaine Buck Louis, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States
6:40 PM–7:05 PM	Ecological Developmental Biology: Gene Expression in the Real World	Scott Gilbert, Swarthmore College, Swarthmore, PA, United States
7:05 PM–7:30 PM	Overview of Developmental Basis of Disease: DOHaD Focus	Mark Hanson, University of Southampton, Southampton General Hospital, United Kingdom
7:30 PM–7:55 PM	Overview of Developmental Basis of Disease: Environmental Impacts	Gwen Collman, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
7:55 PM–8:15 PM	Animal Models for Testing the DOHaD Hypothesis	John Rogers, United States Environmental Protection Agency, Research Triangle Park, NC, United States
8:15 PM–8:35 PM	Review of Epigenetics As the Underlying Mechanism of Developmental Basis of Disease	Shuk Mei Ho, University of Cincinnati, Cincinnati, Ohio, United States
8:35 PM	General Discussion: Integration of Developmental Basis of Disease	Jerrold Heindel, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States

Day 2
Tuesday, December 8, 2009

Session II: Developmental Basis of Cancer

Session Chair: Sue Fenton, United States Environmental Protection Agency, Research Triangle Park, NC, United States

Time	Topic	Speaker
7:00 AM–8:00 AM	Continental Breakfast
7:00 AM–5:30 PM	Registration
8:05 AM–8:25 AM	Fetal Arsenic Exposure and Adult Cancer	Michael Waalkes, NCI at the National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
8:25 AM–8:45 AM	Cancer As Development Gone Awry: The Case for BPA	Ana Soto, Tufts University, Boston, MA, United States
8:45 AM–9:05 AM	Early BPA Exposure Alters the Proteome and Susceptibility for Mammary Cancers in Rodents	Coral Lamartiniere, University of Alabama at Birmingham, Birmingham, AL, United States
9:05 AM–9:25 AM	Early Life Estrogens and Prostate Cancer in an Animal Model	Gail Prins, University of Illinois, Chicago, Illinois, United States
9:25 AM–9:45 AM	DES Model: Cancer in Animals and Humans	Retha Newbold, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
9:45 AM–10:05 AM	The Challenge of Understanding the Significance of Age at Exposure in Humans: DDT and Breast Cancer As a Case Study	Barbara Cohn, Public Health Institute, Berkeley, CA, United States
10:05 AM–10:40 AM	General Discussion
10:40 AM–11:00 AM	Break

 

Session III: National Children’s Studies

Antonia Calafat, Center for Disease Control, Atlanta, GA, United States and Babasaheb Sonawane, United States Environmental Protection Agency, Washington, DC, United States

Time	Topic	Speaker
11:00 AM–11:10 AM	Introduction of Longitudinal Children’s Studies and Worldwide Cohorts	Kimberly Gray, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
11:10 AM–11:25 AM	United States National Children’s Study	Christina Park, National Children’s Study, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States
11:25 AM–11:55 AM	The Norwegian Mothers and Child Study (MOBA) Research Opportunities and Ongoing Projects/International Birth Cohort Studies	Fujio Kayama, Jichi Medical School, Shimotsuke, Japan Merete Eggesbo, National Institute of Public Health, Oslo, Norway
11:55 AM–12:10 PM	Using Biomonitoring to Assess Perinatal Exposure	Antonia Calafat Center for Disease Control, Atlanta, GA, United States
12:10 PM–12:20 PM	General Discussion
12:20 PM–1:30 PM	Lunch on your own

Session IV: Obesity/Diabetes/Metabolic Syndrome

Session Co-Chairs: William Slikker, Jr., National Center for Toxicological Research, Jefferson, AR, United States and Robert E. Chapin, Pfizer Global Research and Development, Groton, CT, United States

Time	Topic	Speaker
1:35 PM–2:00 PM	Environmental Estrogens and Obesity in Animal Models	Fred vom Saal, University of Missouri, Columbia, MO, United States
2:00 PM–2:20 PM	Obesogens, Stem Cells, and the Maternal Programming of Obesity	Bruce Blumberg, University of Southern CA, Irvine, CA, United States
2:20 PM–2:45 PM	Developmental Exposure to Organophosphates and Obesity	Ted Slotkin, Duke University, Durham, NC, United States
2:45 PM–3:10 PM	Tobacco Inhaled Products During Pregnancy and Later Body Composition in Humans	Michael Toschke, Kings College, London, United Kingdom
3:10 PM–3:30 PM	Metabolic Syndrome Epigenetic Programming: Sex Dictates Placenta Response to Diet	Claudine Junien, INSERM, Paris, France
3:30 PM–3:45 PM	General Discussion
3:45 PM–4:05 PM	Break

 

Session V: Developmental Basis of Immune Diseases

Session Co-Chairs: Rodney Dietert, Ithaca, NY, United State and Keiko Nohara, National Institute for Environmental Studies, Japan

Time	Topic	Speaker
4:05 PM–4:30 PM	Developmental Immune Insult and Patterns of Disease	Rodney Dietert Cornell, Ithaca, NY, United States
4:30 PM–4:50 PM	Maternal Dioxin Exposure Alters Anti-Viral Immune Response	Paige Lawrence, Rochester University, Rochester, NY, United States
4:50 PM–5:05 PM	Prenatal TCDD in Mice Increase Adult Autoimmunity	Steve Holladay, University of Georgia, Athens, GA, United States
5:05 PM–5:25 PM	Prenatal Exposure to Air Pollutants and Epigenetic Alterations in an Inner-City Cohort	Frederica Perera, Columbia University School of Public Health, New York, NY, United States
5:25 PM–6:00 PM	General Discussion
6:00 PM–7:30 PM	Poster Session I with snacks and refreshments

 

Day 3
Wednesday, December 9, 2009

Session VI: Developmental Origins of Reproductive Diseases/Dysfunctions

Session Co-Chairs: Sally Darney, United States Environmental Protection Agency, Research Triangle Park, NC, United States and Ken Takeda, University of Science, Tokyo, Japan

Time	Topic	Speaker
8:10 AM–8:30 AM	Testicular Dysgenesis Syndrome: Human Data and Risk Factors for Children	Katharina Main, Copenhagen University Hospital, Copenhagen, Denmark
8:30 AM–8:50 AM	Human Fetal Testis Xenografts and Antiandrogrens	Kim Boekelheide, Brown University, Providence, RI, United States
8:50 AM–9:10 AM	Secular Trends in Timing of Puberty and Role for Environmental Exposures	Anders Juul, University Hospital, Copenhagen, Denmark
9:10 AM–9:30 AM	Adverse Reproductive Outcomes in Females after Developmental Exposure to Environmental Estrogens: Genistein As an Example	Wendy Jefferson, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
9:30 AM–9:50 AM	Neuroendocrine Mechanisms for Disruption of Female Reproductive Function Following Neonatal Exposure to Environmental Estrogens	Heather Patisaul, North Carolina State University, Raleigh, NC, United States
9:50 AM–10:20 AM	Break
10:20 AM–10:40 AM	Developmental Origins of Polycystic Ovary Syndrome: Primate Model	David Abbott, University of Wisconsin, WI, United States
10:40 AM–11:00 AM	Developmental Reprogramming of Tumor Suppressor Gene Penetrance by Xenoestrogens	Cheryl Walker, MD Anderson Cancer Center, Smithfield, TX, United States
11:00 AM–11:25 AM	In Utero Origin of Gynegologic Disorders: Case for the Ovarian Dysgenesis Syndrome	Germaine Buck Louis, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States
11:25 AM–11:45 AM	Discussion
11:45 AM–1:00 PM	Lunch on your own

 

Session VII: Developmental Origins of Neurobehavioral Deficits and Abnormalities

Session Chair: Philippe Grandjean, University of Southern Denmark, Odense, Denmark

Time	Topic	Speaker
1:05 PM–1:30 PM	Developmental Exposure to Maneb and Parquat—Implications for a Fetal Basis of Adult Disease Hypothesis in a Animal Model of Parkinson's Disease	Mona Thiruchelvam, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, United States
1:30 PM–1:55 PM	Effects of Perfluorinated Compounds and Brominated Flame Retardants on Brain Development and Behavior in a Rodent Model	Per Eriksson, Uppsala University, Uppsala, Sweden
1:55 PM–2:30 PM	Developmental Thyroid Hormone Insufficiency and Brain Function	Mary Gilbert, United States Environmental Protection Agency, Research Triangle Park, NC, United States
2:30 PM–3:00 PM	Effects of Early Low-Level Lead Exposure on Human Brain Structure, Organization and Function	Kim Cecil, University of Cincinnati, Cincinnati, OH, United States
3:00 PM–3:30 PM	Break
3:30 PM–3:55 PM	Developmental Neurotoxicity Associated with Organochlorine Exposures in Spanish Birth Cohorts	Jordi Julvez, Harvard School of Public Health, Boston, MA, United States Jordi Sunyer, Center for Research in Environmental Epidemiology, Barcelona, Spain
3:55 PM–4:20 PM	Neurobehavioral Consequences of Prenatal Phthalate Exposure in a Multiethnic Cohort	Stephanie Engel, Mt Sinai School of Medicine, New York, NY, United States
4:20 PM–4:45 PM	Contribution by Pesticide Exposure to Silent Pandemic of Developmental Neurotoxicity	Philippe Grandjean, University of Southern Denmark, Odense, Denmark
4:45 PM–6:00 PM	General Discussion
6:00 PM–7:30 PM	Poster Session II with snacks/refreshments

Day 4
Thursday December 10, 2009

Session IIX: Breakfast Session

Time	Topic	Speaker
7:30 AM–5:00 PM	Registration
7:30 AM–8:30 AM	Cancer, Reproductive, Immune, Neurodegenerative/ Neurobehavior, Obesity, Transgenerational	Scientists attending who are working in these areas will meet together over breakfast to assess the current status in their field, data gaps and needs. One slide will be prepared for each area which will be presented in the meeting summary.

 

Session IX: Clinical and Industry Perspective

Session Chair: Don Mattison, Eunice Kennedy Shriver National Institute of Child Health and  Human Development, Bethesda, MD, United States

Time	Topic	Speaker
8:30 AM–8:45 AM	Can Current Vs. Long-Term Health Consequences of Infant Feeding	Michael S. Kramer, McGill University, Montreal, Quebec, Canada
8:45 AM–9:00 AM	Understanding the Role of Environmental Agents in Combination with Early Nutrition on Short- and Long-Term Health Outcomes—An Industry Perspective	Deshanie Rai, Mead Johnson Nutritionals, Evansville, IN, United States
9:00 AM–9:15 AM	Discussion
9:15 AM–9:45 AM	Break

 

Session X: Mechanisms and Pathways

Session Co-Chairs: Bruce Fowler, Agency for Toxic Substances and Disease Registry, Atlanta, GA, United States and Yasunobu Aoki, National Institute for Environmental Studies, Research Center for Environmental Risk, Ibaraki, Japan

Time	Topic	Speaker
9:50 AM–10:25 AM	The Assessment of Combined Chemical Exposures—Application to Cumulative Risk Assessment of Antiandrogens	Andreas Kortenkamp, University of London, United Kingdom
10:25 AM–10:50 AM	Perinatal Development of Metabolic and Physiological Systems Can Affect the Pharmacokinetics of Endocrine-Active Compounds in Rodents and Non-Human Primates	Daniel Doerge, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, United States
10:50 AM–11:45 AM	Panel Discussion	Panel Members: Shuk Mei Ho, University of Cincinnati, Cincinnati, OH, United States; Cheryl Walker, MD Anderson Cancer Center, Smithfield, TX, United States; Julian Preston, United States Environmental Protection Agency, Research Triangle Park, NC, United States
11:45 AM–1:15 PM	Lunch—Buffet Lunch Provided

 

Session XI: Regulatory Challenges and Approaches

Session Co-Chairs: Bruce Fowler, Agency for Toxic Substances and Disease Registry, Atlanta, GA, United States and Yasu Aoki, National Institute for Environmental Studies, Japan

Time	Topic	Speaker
1:15 PM–1:35 PM	Late Lessons from Early Warnings	Lynn Goldman, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
1:35 PM–2:20 PM	Panel Discussion	Panel Members: David Hattan, Food and Drug Administration, College Park, MD, United States; Robert Nelson, Food and Drug Administration, College Park, MD, United States; Elaine Francis, United States Environmental Protection Agency, Washington D.C., United States; Roberto Bertollini World Health Organization, Geneva, Switzerland; Bob Sonawane, United States Environmental Protection Agency, Washington D.C., United States
2:20 PM–2:45 PM	Break

 

Session XII: Transgenerational Effects

Session Chair: Jerrold Heindel, National Institute of Environmental Health  Sciences, Research Triangle Park, NC, United States and Lisa Chadwick, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States

Time	Topic	Speaker
2:50 PM–3:15 PM	Epigenetic Transgenerational Actions of Endocrine Disruptors on Reproduction and Disease: The Ghosts in the Genome	Michael Skinner, Washington State University, Pullman, WA, United States
3:15 PM–3:40 PM	Transgenerational Effects of Dioxin on the Endometriosis Phenotype	Kevin Osteen, Vanderbilt University, Nashville, TN, United States
3:40 PM–4:00 PM	Transgenerational Changes after Embryonic Exposure to Plasticizers Phthalate	Kwan Hee Kim Washington State University, Pullman, WA, United States
4:00 PM–4:20 PM	Perinatal Exposure of Rats to Bisphenol A Affects Fertility of Male Offspring	Smita Salian Mehta, National Center for Pre-Clinical Research in Reproductive and Genetic Toxicology, National Institute for Research in Reproductive Health (Indian Council of Medical Research), Parel, Mumbai
4:20 PM–4:40 PM	General Discussion	Jerrold Heindel, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
4:20 PM	Future Directions and Meeting Summary Reports from Breakfast Disease Focused Sessions, Clinical and Industry Perspective, Mechanisms and Regulatory Challenges Breakouts	Jerrold Heindel, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
5:30 PM	Meeting End

Sponsors

The Society of Toxicology

National Institute of Environmental Health Sciences

ATSDR

Centers for Disease Control and Prevention

Eunice Kennedy Shriver National Institute of Child Health and Human Development

European Environment Agency

International Union of Toxicology

National Cancer Institute

National Center For Toxicological Research

National Institute for Environmental Studies

National Institute of Child Health and Human Development

Superfund Research Program

U.S. Environmental Protection Agency

World Health Organization

 

Organizing Committee

Members:

Sally Darney, Ph.D.
National Program Director for Human Health
Office of Reseach and Development,
U.S. Environmental Protection Agency

Bruce Fowler, Ph.D.
Assistant Director for Science,
Division of Toxicology and Environmental Medicine,
ATSDR,
Centers for Disease Control

Philippe Grandjean, M.D.
Professor, Head of Research
niversity of Southern Denmark

Jerrold Heindel, Ph.D.
Chief Cellular, Organs and Systems Pathobiology Branch
National Institute of Environmental Health Sciences

Donald Mattison, M.D.
Senior Advisor to the Director of NICHD
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health, HHS

William Slikker, Jr., Ph.D.
Director, National Center for Toxicological Research
U.S. Food and Drug Administration

Registration Information

Registration Fees:

Registration Type	Early Bird	Standard	On-Site
	July 29, 2009	July 30–Nov. 10, 2009	After Nov. 10, 2009
SOT Member	$400	$450	$500
Non-Member	$500	$550	$600
Student	$75	$100	$100

Fees include all general sessions, program materials, continental breakfasts, breaks, and the opening reception.

Registration fees may be paid by check (please list all registrants on the check stub), money order, credit card (Visa, MasterCard, Diner's Club, or American Express), or U.S. Government Purchase Orders (check must be drawn from the U.S. Department of Treasury). Please use the registration form.

No telephone registrations will be accepted.

To register, please send the registration form and payment or credit card information by one of the following methods:

1. Mail/USPS Express packages:
   PPTOXII CCT, Society of Toxicology
   1821 Michael Faraday Drive, Suite 300
   Reston, VA 20190
2. Tel: (703) 438-3115
   
3. Fax: (703) 438-3113
   NOTE: To prevent double-billing, if you are registering by fax, DO NOT mail your original registration form. SOT needs only one copy for processing.

DEADLINE:  After November 10, 2009, you must register on-site.

CANCELLATION REFUND POLICY:
All requests for cancellations and/or refunds must be received in writing to SOT Headquarters by November 20, 2009. These refunds will be processed, less a $30 fee, following the Workshop.

Attire:
The official attire for the meeting is business casual. No coats or ties are required! We encourage you to bring comfortable clothing.

Hotel Information

Loews Miami Beach Hotel
1601 Collins Avenue
Miami Beach, Florida 33139
Phone: (305) 604-1601
Fax: (305) 604-3999

• Located directly on the beach in South Beach's fashionable and diverse Art Deco District
• Minutes from shopping, restaurants, and nightlife
• Only one block from Lincoln Road and three blocks from the Miami Beach Convention Center

The PPTOXII conference will be held at the Loews Miami Beach Hotel located in South Beach Miami. One of the newest hotels in the South Beach area, the Loews Hotel combines the architectural charm of the art deco period with world class service. The hotel amenities include: 

• Oceanfront swimming pool and Jacuzzi and private cabanas
• 6 restaurants and bars, including Emeril's South Beach
• Direct access to beach
• Wide variety of water sports
• Concierge Service
• Self or valet parking:
• Valet parking is $34; Overnight is $25
• Elemis Spa and Fitness Center
• 24-hour in-room dining

The Society of Toxicology has reserved a block of rooms at a discounted rate at the Loews Hotel Miami. The room rate is $189 Single /Double standard rooms. There is an additional $25 charge per third and fourth person in the room. The room tax is 13%. To make a hotel reservation please call the Hotel Reservations Department at 877-LOEWS-MB or call US (305) 604-1601 and mention that you are with the Society of Toxicology and reference SOTD06 in order to receive the discounted rates or you can e-mail lmbreservations@loewshotels.com and request a room (please indicate that you are with SOT and please provide a credit card number).

Deadline:
The Housing Deadline has been extended to November 11, 2009. Please make your hotel reservation prior to November 11, 2009, in order to receive the SOT discounted rate. Rooms reserved after this date will be at a substantially higher rate.

Transportation

Airports:
Miami International Airport • 12 miles from Loews Miami Beach Hotel
Fort Lauderdale Hollywood International Airport • 29 miles from Loews Miami Beach Hotel

Airline Information:
To book your flights, you may contact SOT's travel agents:
American Express Travel, (800) 872-9954, columbiamdctn@aexp.com  or Carlson Wagonlit, (800) 525-6061, direct (703) 276-2040, NMarkun@carlsonwagonlit.com.

Expedia: www.expedia.com
Priceline: www.priceline.com
Travelocity: www.travelocity.com
AirTran: www.airtran.com
American Airlines: www.aa.com
US Airways: www.usair.com
American West Airlines: www.americanwest.com
Continental Airlines: www.continental.com
United Airlines: www.united.com
Delta: www.delta.com/home/index.jsp.

Driving Directions from Airports:

Miami International Airport to Loews Miami Beach Hotel

• Follow airport signs to Le Jeune Road South (NW 42nd Avenue)
• Take Le Jeune Road to SR-836 East (Dolphin Expressway)
• Travel on SR-836 East, through the toll plaza until I-395 East
• Continue on I-395 Towards Miami Beach (MacArthur Causeway)
• Stay on the left hand side and exit on Alton Road North
• Continue on Alton Road and turn right on 16th Street

Fort Lauderdale International Airport to Loews Miami Beach Hotel

• Follow airport signs to I-595 West
• Take I-595 to I-95 South
• Continue until I-195 East
• Travel on I-195 and take Julia Tuttle Causeway East
• Stay in the far-right lane and take Alton Road South Exit
• Continue on Alton Road and turn left on 16th Street
• Loews Miami Beach is directly ahead

Location

Miami Beach & South Beach:
Miami Beach Florida has been setting the bar for "cool" for decades. From the Rat Pack to Versace, this has been home to the world’s elite celebrities. South Beach, the tip of Miami Beach south of Dade Avenue, is best known today for runway models and exclusive nightclubs. As long-time Miami Beach fan Jackie Gleason used to say, “How sweet it is!”

Nightlife:
If you come to Miami South Beach, it is the place to see and be seen. Along the sparkling Miami shores at the Nikki Beach Club, supermodels slip out of teepee cabanas wearing only the bare necessities. The ultra hip crowd comes to Mynt to chill against a backdrop of sleek space age décor and cool-hued lighting.

You’ll reach nightclub nirvana at the multi-level dance floors of Opium Garden, with its lush Asian themes, and the exclusive Prive lounge. Three poolside theme rooms converge at the Shore Club’s Skybar. DJs rule at Crobar, featuring three state-of-the-art dance floors. Mansion is home to events like the Winter Music Conference and White Party benefits.

The High Life:
Bal Harbour Shops, is a Riviera-style mix of palm trees, fountains, and chic shops like Cartier, Fendi, Hermes, Prada, and Tiffany.

After the famous fashion designer was gunned down on the front steps of the Versace Mansion on 11th and Ocean, it became a rather somber local curiosity. But this beautifully intricate and palatial estate, originally called Casa Casuarina, is a 1930s architectural gem designed as a replica of Columbus’s son’s home in Santo Domingo.

Although rumors of a Versace Museum never bore fruit, you can take solace by viewing the treasures of the Bass Museum of Art. The striking new building includes an outdoor sculpture garden, and has featured artists such as Picasso and Kahlo. The museum’s permanent collection focuses on Renaissance and baroque art.

Stroll along a self-guided tour of the pastel architectural styling of the Art Deco District. Or visit the historic Mediterranean-revival neighborhood of Plaza De Espana. A convertible is the perfect vantage point to view to clean architectural lines of restored mid-century hotels like the Fontainbleu and Eden Roc while cruising up Collins Avenue.

Miami Beaches:
Miami Beach lies on a barrier island, with beaches on the Atlantic Ocean side. Most of this stretch is bumper-to-bumper hotels and condos, but public beach access is plentiful, with lifeguards, bathroom, and concession stands.

The sands are hard packed, but a wooden beachside boardwalk runs from 21st to 46th streets. On the north end of Miami Beach, you’ll find Haulover Beach, home of the only clothing-optional stretch of beach in town. Lummus Park (aka South Beach) is a swath of star-studded white sands from 5th to 15th Street.

Links:
Vida Americana (Maps)
Greater Miami Convention & Visitors Bureau

Art Deco Historic District:
The Miami Art Deco District is dedicated to protecting the buildings that best represent Miami’s classic architecture. The buildings were revolutionary when they were constructed in the early 1900’s and they have influenced other buildings all over the world.
Several tours explore the Art Deco District including the “Underworld Tour” that will take you to former hotspots of illegal activity like Al Capone’s office! The Art Deco District is a fun, interesting place that begs to be explored. Be sure to visit the next time you’re in the Miami Area.

Miami Art Deco Historic District Contact Information:
The Art Deco Welcome Center
1200 Ocean Drive
Miami, FL 33139
(305) 531-3484
For tour pricing and other information, please call (305) 672-2014

Besides South Beach's Historic Art Deco District, located right outside our door, other nearby attractions include the Miami Seaquarium, Miami Metro Zoo, Miccosokee Seminole Indian Village, Fairchild Tropical Garden, and Ancient Spanish Monastery.
Miami is home to a host of local professional teams including the Miami Dolphins (NFL), Miami Heat (NBA), Florida Marlins (MLB), and Florida Panthers (NHL). Other area sports include Jai-Alai in Miami and Dania, horse racing in Hialeah and Gulfstream Park, as well as dog racing in West Flagler and Biscayne.

Climate:
December is a great time of year in Miami. For current weather reports please visit:
Google Weather

Previous SOT CCT Meetings

The first PPTOX meeting was held in 2007 in Torshavn, Faroe Islands. View the conference Web site.

• Past CCT Meetings